Objective: To find if there was any difference in monocytes/macrophages infiltration and monocyte chemoattractant protein-1(MCP-1) expression between rapidly progressive periodontitis (RPP) and adult periodontitis (AP) tissues.
Methods: Inflamed gingival specimens (20) were obtained from RPP(14) and AP(6) patients, and specimens from clinically healthy subjects (H,6) as control. The monocytes/macrophages and MCP-1 expression were detected by immuno-histochemistry SP assay with antibodies against CD14 and CD68, and rabbit anti-MCP-1 antibody.
Results: There were no differences in the mean counts (+/- SD) of monocytes/macrophages and MCP-1 positive cells between RPP and AP groups.
Conclusion: Though rapid and severe periodontal destruction occurs in RPP, there is no differences in monocytes/macrophages infiltration and MCP-1 expression in gingival tissues between rapidly progressive periodontitis and adult periodontitis patients.