Comparative evaluation of two hemagglutination tests for the detection of anti-Helicobacter pylori antibodies

M Nilius; T Wex; G Müller-Dietz; A Leodolter; D Schilling; P Malfertheiner

doi:10.1016/s0732-8893(01)00306-6

Comparative evaluation of two hemagglutination tests for the detection of anti-Helicobacter pylori antibodies

Diagn Microbiol Infect Dis. 2001 Dec;41(4):221-3. doi: 10.1016/s0732-8893(01)00306-6.

Authors

M Nilius¹, T Wex, G Müller-Dietz, A Leodolter, D Schilling, P Malfertheiner

Affiliation

¹ Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University, Magdeburg, Germany.

PMID: 11777664
DOI: 10.1016/s0732-8893(01)00306-6

Abstract

Two hemagglutination assays (IHAs) for detecting anti-H. pylori antibodies were evaluated. In 257 patients, both tests revealed sensitivity or specificity values between 71-79% or 81-82%, respectively, which were lower than those of an anti-H. pylori ELISA. Notably, the sensitivities of both IHAs varied in subgroups of patients between 48-95%. Based on the validation, the IgG-ELISA is superior to both IHAs tested, and therefore, should be used in routine diagnostics.

Publication types

Comparative Study
Evaluation Study

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antibodies, Bacterial / analysis*
Enzyme-Linked Immunosorbent Assay / methods
Helicobacter Infections / diagnosis*
Helicobacter Infections / immunology
Helicobacter Infections / microbiology
Helicobacter pylori / immunology
Helicobacter pylori / isolation & purification*
Hemagglutination Tests / methods
Humans
Middle Aged
Reagent Kits, Diagnostic
Sensitivity and Specificity
Sheep

Substances

Antibodies, Bacterial
Reagent Kits, Diagnostic