Objective: To investigate possible mechanism of the influence of zafirlukast to anoxic pulmonary hypertension in rats.
Methods: Forty wistar rats were divided into four groups in random: (1) control group; (2) anoxic pulmonary hypertension group; (3) zafirlukast preventive group; (4) zafirlukast therapeutic group. Pulmonary arterial pressure was measured, naemo kinitic indexes were recorded.
Results: In the anoxic group and control group, the difference of mPAP was remarkable, P < 0.01. When zafirlukast preventive group and the therapeutic group compared with the control group, there was no statistical difference, P > 0.05. When the preventive group and the therapeutic group compared with the hypoxia group, P < 0.01. In the hypoxia group, the content of NO in the plasma, broncho-alveolar lavage solution, and the lung tissue showed remarkable significance compared with that of control group, P < 0.01. The content of NO2-./NO3-. in the preventive group showed remarkable significance compared with hypoxia group, P < 0.05, P < 0.01. The content of NO2-./NO3-. in the therapeutic group showed remarkable significance compared with hypoxia group, P < 0.01. The content of collagen in hypoxia group was remarkable highened compared with that of control group, P < 0.01. The content of collagen in preventive group and therapeutic group showed remarkable significance compared with hypoxia group, P < 0.01, P < 0.05.
Conclusions: The results indicate that zafirlukast can lower anoxic pulmonary hypertension, one of its mechanisms may be related with its depressing the sediment of collagen on lung tissue, adjusting NO level in rats and anti-damaging effect of free radicals.