Vinorelbine-associated myelopathy in a patient who previously received paclitaxel: a case report

Med Oncol. 2001;18(1):95-7. doi: 10.1385/MO:18:1:95.

Abstract

Vinorelbine seems to cause less neurotoxicity than other vinca alkaloids because of its selective activity on mitotic cells over axonal microtubules. Clinical trials report very mild peripheral neurotoxicity with distal paresthesiae and there are no reports of myelopathy in these series of patients. The authors describe a patient who developed a rare event of myelopathy while on vinorelbine for non-small-cell lung cancer.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Phytogenic / adverse effects*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Female
  • Humans
  • Lung Neoplasms / drug therapy
  • Magnetic Resonance Imaging
  • Middle Aged
  • Paclitaxel / therapeutic use*
  • Spinal Cord / pathology
  • Spinal Cord Diseases / chemically induced*
  • Spinal Cord Diseases / pathology
  • Vinblastine / adverse effects*
  • Vinblastine / analogs & derivatives*
  • Vinblastine / therapeutic use
  • Vinorelbine

Substances

  • Antineoplastic Agents, Phytogenic
  • Vinblastine
  • Paclitaxel
  • Vinorelbine