Objective: To study the effect of Sijunzi Decoction (SJZD) on serum soluble intercellular adhesive molecule-1 (sICAM-1), interleukin-15 (IL-15) and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) in patients of Spleen-Deficiency.
Methods: Serum sICAM-1, IL-15 and monocyte ADCC of 66 Spleen-Deficiency patients were determined by enzyme-linked immunosorbent assay and modified thiazole blue test.
Results: Serum sICAM-1 of Spleen-Deficiency patients increased, IL-15 secretion decreased and monocyte ADCC function reduced, which displayed as lowered immune function. After SJZD treatment, all the above-mentioned parameters were normalized.
Conclusion: SJZD could enhance immune function of organism by strengthening Spleen and tonifying Qi.