6-mercaptopurine: efficacy and bone marrow toxicity in childhood acute lymphoblastic leukemia. Association with low (thio)purine enzyme activity

Adv Exp Med Biol. 2000:486:271-5. doi: 10.1007/0-306-46843-3_53.
No abstract available

Publication types

  • Review

MeSH terms

  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Bone Marrow / drug effects*
  • Child
  • Humans
  • Mercaptopurine / adverse effects*
  • Mercaptopurine / therapeutic use
  • Methyltransferases / genetics
  • Methyltransferases / metabolism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Purines / metabolism

Substances

  • Antimetabolites, Antineoplastic
  • Purines
  • Mercaptopurine
  • Methyltransferases
  • thiopurine methyltransferase
  • purine