Synthesis and characterization of (99m)Tc- and (188)Re-complexes with a diamido-dihydroxymethylenephosphine-based bifunctional chelating agent (N(2)P(2)-BFCA)

Nucl Med Biol. 2002 Jan;29(1):83-9. doi: 10.1016/s0969-8051(01)00280-3.

Abstract

A diamido-dihydroxymethylenephosphine (N(2)P(2)) bifunction chelating agent (BFCA) was shown to form well-defined (99m)Tc- and (188)Re-chelate structures. The 4, 4-bis [bis-hydroxymethyl-phosphonyl-propylcarbonmoyl]-butyric acid bifunctional chelating agent (N(2)P(2)-BFCA) formed stable complexes with (99m)Tc and (188)Re in >95% yield with high radiochemical purity (RCP). The biodistribution of the (99m)Tc- and (188)Re-N(2)P(2)-BFCAs after intravenous injection studied in normal mice showed the activity was excreted primarily via renal-urinary pathway indicating their use for labeling peptides with (99m)Tc and (188)Re.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chelating Agents / chemical synthesis*
  • Chelating Agents / pharmacokinetics
  • Drug Stability
  • Mice
  • Radioisotopes
  • Rhenium / chemistry*
  • Structure-Activity Relationship
  • Technetium Compounds / chemical synthesis*
  • Technetium Compounds / pharmacokinetics
  • Tissue Distribution

Substances

  • Chelating Agents
  • Radioisotopes
  • Technetium Compounds
  • Rhenium