Antibiotic-induced recurring interstitial nephritis

Pediatr Nephrol. 2002 Jan;17(1):50-1. doi: 10.1007/s004670200009.

Abstract

Acute interstitial nephritis (AIN) is often induced by drug therapy and accounts for 1%-3% of adult cases of renal failure. A 13-year-old white female with cystic fibrosis developed two episodes of biopsy proven AIN following antibiotic use over a 5-year period. The first episode resolved with pulse steroid therapy and the second resolved without intervention. Steroid therapy may play a role in aborting subsequent AIN attacks.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Biopsy
  • Clavulanic Acids / adverse effects*
  • Drug Therapy, Combination / adverse effects*
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Kidney / pathology
  • Methylprednisolone / therapeutic use
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / drug therapy
  • Nephritis, Interstitial / pathology
  • Penicillins / adverse effects*
  • Piperacillin / adverse effects*
  • Ticarcillin / adverse effects*

Substances

  • Clavulanic Acids
  • Glucocorticoids
  • Penicillins
  • ticarcillin-clavulanic acid
  • Ticarcillin
  • Piperacillin
  • Methylprednisolone