Abstract
We have observed that human neutrophils (polymorphonuclear leukocytes [PMNs]) have an increased growth-inhibitory and killing effect on a strain of Candida albicans with a deletion of CHK1, a gene encoding a putative histidine kinase. The PMN effect was not due to increased phagocytosis of the null strain. This observation may partially explain the reduced virulence in a hematogenously disseminated murine model of candidiasis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Candida albicans / enzymology*
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Candida albicans / immunology
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Cells, Cultured
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
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Histidine Kinase
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Humans
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Neutrophils / cytology
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Neutrophils / immunology*
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Neutrophils / microbiology
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Phagocytosis / immunology*
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Protein Kinases / immunology*
Substances
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Granulocyte-Macrophage Colony-Stimulating Factor
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Protein Kinases
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Histidine Kinase