Unusual morphology in a case of large granular cell leukemia

S Galimberti; R Riccioni; A Azzarà; R Testi; R Fazzi; C Testi; M Petrini

doi:10.1007/s002770100374

Unusual morphology in a case of large granular cell leukemia

Ann Hematol. 2001 Dec;80(12):755-7. doi: 10.1007/s002770100374. Epub 2001 Oct 13.

Authors

S Galimberti¹, R Riccioni, A Azzarà, R Testi, R Fazzi, C Testi, M Petrini

Affiliation

¹ Hematology Division, Department of Oncology, Transplants and Advanced Technologies, University of Pisa, Ospedale S.Chiara, Via Roma 67, 56100 Pisa, Italy.

PMID: 11797119
DOI: 10.1007/s002770100374

Abstract

Large granular lymphocyte proliferative status represents a group of clonal and nonclonal lymphoproliferative disorders of natural killer (NK) or T-cell lineages with common morphological features. Cellular differences may sustain the clinical polymorphism observed in these disorders. Here we report a case of large granular lymphocyte disease unusually expressing CD4+CD8+ clonal T cells and atypical cell morphology in bone marrow.

Publication types

Case Reports

MeSH terms

Arthritis, Rheumatoid / complications
Bone Marrow Cells / pathology
CD4-Positive T-Lymphocytes / pathology
CD8-Positive T-Lymphocytes / pathology
Diabetic Nephropathies / complications
Humans
Immunohistochemistry
Immunophenotyping
Lymphocytes / pathology*
Lymphoproliferative Disorders / complications
Lymphoproliferative Disorders / pathology*
Male
Middle Aged
Prostatic Neoplasms / complications
Urinary Bladder Neoplasms / complications