Current management of fallopian tube carcinoma

Curr Opin Obstet Gynecol. 2002 Feb;14(1):27-32. doi: 10.1097/00001703-200202000-00005.

Abstract

The management of fallopian tube carcinoma is similar to that of ovarian carcinoma. Surgery should consist of bilateral salpingo-oophorectomy, total abdominal hysterectomy, comprehensive surgical staging also including a systematic pelvic and para-aortic lymphadenectomy, and aggressive debulking in patients with advanced tumour. Patients with apparently early stage low-risk fallopian tube carcinoma, not submitted to complete surgical staging, as well as those with early stage high-risk disease should receive adjuvant single-agent carboplatin. Patients with advanced disease should undergo paclitaxel- plus carboplatin-based chemotherapy. Second-line treatment for persistent/recurrent disease should be mainly based on the platinum-free interval, whereas secondary cytoreduction should be considered only for highly selected patients with localized, late relapse.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carboplatin / administration & dosage
  • Chemotherapy, Adjuvant
  • Cisplatin / administration & dosage
  • Drug Administration Schedule
  • Fallopian Tube Neoplasms / drug therapy
  • Fallopian Tube Neoplasms / pathology
  • Fallopian Tube Neoplasms / surgery*
  • Fallopian Tubes* / surgery
  • Female
  • Humans
  • Ovariectomy*
  • Paclitaxel / administration & dosage

Substances

  • Carboplatin
  • Paclitaxel
  • Cisplatin