[Thrombolytic therapy as pretreatment before vascular operations and radiologic interventions]

A Laczkó; G V Szabó; Z Szeberin; B Nemes; I Bobek; V Kristóf; L Selmeci; G Acsády

[Thrombolytic therapy as pretreatment before vascular operations and radiologic interventions]

Magy Seb. 2001 Dec:54 Suppl:69-73.

[Article in Hungarian]

Authors

A Laczkó¹, G V Szabó, Z Szeberin, B Nemes, I Bobek, V Kristóf, L Selmeci, G Acsády

Affiliation

¹ Semmelweis Egyetem Altalános Orvostudományi Kar, Er- és Szívsebészeti Klinika, 1122 Budapest, Városmajor utca 68. [email protected]

PMID: 11816152

Abstract

The authors describe their 60 cases of thrombolysis with steptokinase (SK). Thrombolysis was required in 55 patients because of arterial, while in 5 patients because of venous side thrombosis. The 73% of the patients with arterial occlusion where thrombolysis was applied belonged Fountain stage IV, while 27% to Fountain stage III. Graft occlusion occurred in 60% of all cases and the acute or subacute thrombosis of the native vessels required thrombolysis in 40%. The thrombolysis alone was sufficient in 26 patients, while it was completed with PTA in 9, with PTA and implantation of stent in 1 and with vascular surgical procedure in 10 cases. Reconstruction surgery was the final solution in 4 patients, for whom the thrombolysis was inadequate. Amputation was unavoidable in 8 cases. The thrombolysis therapy was successful in 77% in our experience. The high number of hemorrhagic complications was due to the bleeding of puncture hole. It needed surgical suture in 10 cases.

MeSH terms

Angioplasty / methods*
Arterial Occlusive Diseases / complications
Arterial Occlusive Diseases / diagnostic imaging
Arterial Occlusive Diseases / therapy*
Fibrinolytic Agents / administration & dosage
Fibrinolytic Agents / adverse effects
Fibrinolytic Agents / therapeutic use*
Hemorrhage / chemically induced
Humans
Plasminogen Activators / administration & dosage
Plasminogen Activators / adverse effects
Plasminogen Activators / therapeutic use*
Radiography, Interventional*
Streptokinase / administration & dosage
Streptokinase / adverse effects
Streptokinase / therapeutic use*
Thrombolytic Therapy* / adverse effects
Thrombolytic Therapy* / methods
Thrombosis / complications
Thrombosis / therapy*
Treatment Outcome
Urokinase-Type Plasminogen Activator / administration & dosage
Urokinase-Type Plasminogen Activator / adverse effects
Urokinase-Type Plasminogen Activator / therapeutic use*

Substances

Fibrinolytic Agents
Streptokinase
Plasminogen Activators
Urokinase-Type Plasminogen Activator