Abstract
Immunotherapies designed to prevent infection serve as an increasingly important adjunct to bone marrow transplantation (BMT). T cell immunotherapies are particularly useful for the control of virus infections, provided that T cell populations are free of graft-vs-host (GVH) activity. In this review, we describe positive and negative selection methods with which donor T cell populations devoid of GVH activity can be prepared for transfer to the immunodeficient BMT recipient. The support of patients with T cell immunotherapies may ultimately revolutionize BMT, elevating the procedure from a salvage to a front-line treatment strategy for otherwise fatal disorders.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bone Marrow Transplantation / adverse effects*
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Bone Marrow Transplantation / immunology
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Cell Separation
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Epstein-Barr Virus Infections / etiology
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Epstein-Barr Virus Infections / immunology
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Epstein-Barr Virus Infections / prevention & control
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Graft vs Host Disease / immunology
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Humans
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Immunotherapy / methods*
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Immunotherapy, Adoptive / methods
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In Vitro Techniques
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Lymphocyte Depletion
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T-Lymphocytes / immunology*
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T-Lymphocytes / transplantation
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Virus Diseases / etiology
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Virus Diseases / immunology
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Virus Diseases / prevention & control*