Inoculation of chicks with viable non-colonizing strains of Campylobacter jejuni: evaluation of protection against a colonizing strain

Richard L Ziprin; Michael E Hume; Colin R Young; Roger B Harvey

doi:10.1007/s00284-001-0088-3

Inoculation of chicks with viable non-colonizing strains of Campylobacter jejuni: evaluation of protection against a colonizing strain

Curr Microbiol. 2002 Mar;44(3):221-3. doi: 10.1007/s00284-001-0088-3.

Authors

Richard L Ziprin¹, Michael E Hume, Colin R Young, Roger B Harvey

Affiliation

¹ Food and Feed Safety Research Unit, Southern Plains Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, 2881 F&B Road, College Station, TX 77845, USA. [email protected]

PMID: 11821932
DOI: 10.1007/s00284-001-0088-3

Abstract

We have treated chicks with viable non-colonizing mutant strains of Campylobacter jejuni to test these as a possible vaccine. We found that intramuscular inoculation with and without adjuvant, and with or without a concomitant oral dose of non-colonizing strains, failed to provoke protective immunity.

MeSH terms

Adjuvants, Immunologic / administration & dosage
Administration, Oral
Animals
Bacterial Vaccines / administration & dosage
Campylobacter jejuni / genetics
Campylobacter jejuni / immunology*
Campylobacter jejuni / pathogenicity*
Chickens / immunology*
Chickens / microbiology*
Digestive System / immunology
Digestive System / microbiology
Food Microbiology
Genes, Bacterial
Injections, Intramuscular
Mutation
Virulence / genetics

Substances

Adjuvants, Immunologic
Bacterial Vaccines