201Tl, 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-furifosmin: relative retention and clearance kinetics in retrogradely perfused guinea pig hearts

Nucl Med Biol. 2002 Feb;29(2):243-54. doi: 10.1016/s0969-8051(01)00288-8.

Abstract

Myocellular kinetics of 201Tl, 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-furifosmin were investigated using retrogradely-perfused guinea-pig hearts. Relative retention decreased in the order 99mTc-MIBI ==> 99mTc-tetrofosmin ==> 99mTc-furifosmin. 201Tl and 99mTc-MIBI exhibited bi- (t1,t2), 99mTc-tetrofosmin and 99mTc-furifosmin triexponential (t1,t2,t3) time-activity-curves. Latest-phase elimination-half-life increased from 201Tl (t2) ==> 99mTc-MIBI (t2) ==> 99mTc-tetrofosmin (t3) ==> 99mTc-furifosmin (t3), showing a significant increase in deteriorating myocardium for all tracers but 99mTc-furifosmin. Delayed elimination in deteriorating myocardium explains at least partly the redistribution phenomenon of 201Tl, and suggests a similar phenomenon for 99mTc-MIBI and 99mTc-tetrofosmin.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Furans / pharmacokinetics*
  • Guinea Pigs
  • In Vitro Techniques
  • Male
  • Myocardium / metabolism*
  • Organophosphorus Compounds / pharmacokinetics*
  • Organotechnetium Compounds / pharmacokinetics*
  • Radiopharmaceuticals / pharmacokinetics*
  • Technetium Tc 99m Sestamibi / pharmacokinetics*
  • Time Factors

Substances

  • Furans
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m Q12
  • technetium tc-99m tetrofosmin
  • Technetium Tc 99m Sestamibi