Abstract
Objective:
The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striatal dopamine transporter levels, which may explain psychostimulant effects in this disorder.
Method:
Single photon emission computed tomography and [(123)I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([(123)I]beta-CIT) were used to assess dopamine transporter availability in nine adult patients with ADHD (eight of whom were stimulant naive) and nine age- and gender-matched healthy comparison subjects.
Results:
Striatal [(123)I]beta-CIT binding did not differ significantly between the ADHD and comparison subjects.
Conclusions:
The findings suggest that a hypothesized dysregulation of dopamine function in ADHD does not entail altered dopamine transporter levels.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Attention Deficit Disorder with Hyperactivity / diagnostic imaging
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Attention Deficit Disorder with Hyperactivity / physiopathology*
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Attention Deficit Disorder with Hyperactivity / psychology
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Cocaine / analogs & derivatives
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Cocaine / pharmacokinetics
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Corpus Striatum / diagnostic imaging
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Corpus Striatum / physiopathology*
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Dopamine Plasma Membrane Transport Proteins
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Female
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Humans
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Iodine Radioisotopes
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Male
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Membrane Glycoproteins*
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Membrane Transport Proteins / physiology*
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Middle Aged
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Nerve Tissue Proteins*
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Tomography, Emission-Computed, Single-Photon*
Substances
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Dopamine Plasma Membrane Transport Proteins
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Iodine Radioisotopes
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
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Cocaine