Creating a bicuspid valve from the aortic wall: a new surgical approach on aortic valve disease (in vitro study)

Eur J Cardiothorac Surg. 2002 Feb;21(2):342-4. doi: 10.1016/s1010-7940(01)01126-5.

Abstract

We described a new technique (called 'bicuspidization'), which is performed by using autogenous material, without replacement of the aortic valves for the surgical treatment of aortic stenosis and/or insufficiency and tested it in in vitro sheep model. Different stress conditions were simulated by applying three different flow patterns (hemodynamic challenge tests) successively by using a centrifugal pump. It was demonstrated that the competency of the new bicuspid valves was excellent (zero insufficiency). There was a 10-11 mm Hg-increase on trans-valvular gradient comparing the normal hearts. The autogenous bicuspid valve has not blocked the way of the coronary flow in the closed position.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Aortic Valve / surgery*
  • Aortic Valve Insufficiency / surgery
  • Aortic Valve Stenosis / surgery
  • Hemodynamics
  • Models, Animal
  • Sensitivity and Specificity
  • Sheep
  • Vascular Surgical Procedures / methods*