Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

Chembiochem. 2001 Jan 8;2(1):69-75. doi: 10.1002/1439-7633(20010105)2:1<69::AID-CBIC69>3.0.CO;2-8.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Epothilones*
  • Humans
  • Indicators and Reagents
  • Lactones / chemical synthesis*
  • Lactones / pharmacology*
  • Microscopy, Electron
  • Models, Molecular
  • Stereoisomerism
  • Thiazoles / chemical synthesis*
  • Thiazoles / pharmacology*
  • Tubulin / metabolism
  • Tubulin / ultrastructure
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • C12,13-cyclopropylepothilone A
  • C12,C13-cyclobutylepothilone A
  • Epothilones
  • Indicators and Reagents
  • Lactones
  • Thiazoles
  • Tubulin