Conservation of the T-cell receptor alpha/delta linkage in the teleost fish Tetraodon nigroviridis

Genomics. 2002 Feb;79(2):241-8. doi: 10.1006/geno.2002.6688.

Abstract

T-cell specific receptors (TCR) are present in all groups] from the jawed vertebrates to the mammals. In teleosts, however, the genes encoding the gamma- and delta-chains have not yet been found, the alpha- and beta-chains have been characterized mainly at the expression level, and genomic organization of these loci remains largely unknown. Here we describe both the genomic organization of the TCR alpha/delta locus in Tetraodon nigroviridis and the transcription of TCRA and TCRD. The TCR alpha/delta locus consists of 13 V alpha/delta segments, a Calpha gene, and 12 Jalpha segments, followed by a Cdelta gene, two Jdelta segments, and several Ddelta segments. However, the genomic organization found in this teleost differs significantly from that which has been observed in mammals and birds: a common set of V segments is used to generate either an alpha- or a delta-chain by genomic inversion, and the size of the locus is small in this vertebrate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosomes, Artificial, Bacterial
  • Conserved Sequence
  • DNA
  • Evolution, Molecular
  • Flounder / genetics
  • Gene Library
  • Genes, T-Cell Receptor alpha / genetics*
  • Genes, T-Cell Receptor delta / genetics*
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Sequence Homology, Amino Acid
  • Tetraodontiformes / genetics*

Substances

  • DNA

Associated data

  • GENBANK/AJ310998
  • GENBANK/AJ310999
  • GENBANK/AJ311000
  • GENBANK/AJ311001
  • GENBANK/AJ311002
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  • GENBANK/AJ320227
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  • GENBANK/AJ410412
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  • GENBANK/AL566139
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