X-linked dystonia ("Lubag") presenting predominantly with parkinsonism: a more benign phenotype?

Virgilio Gerald H Evidente; Katrina Gwinn-Hardy; John Hardy; Dena Hernandez; Andrew Singleton

doi:10.1002/mds.1263

X-linked dystonia ("Lubag") presenting predominantly with parkinsonism: a more benign phenotype?

Mov Disord. 2002 Jan;17(1):200-2. doi: 10.1002/mds.1263.

Authors

Virgilio Gerald H Evidente¹, Katrina Gwinn-Hardy, John Hardy, Dena Hernandez, Andrew Singleton

Affiliation

¹ Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA. [email protected]

PMID: 11835466
DOI: 10.1002/mds.1263

Abstract

"Lubag," or Filipino X-linked dystonia, typically presents with either pure dystonia (that inexorably becomes generalized) or combined dystonia-parkinsonism. We report on three cases of Lubag presenting with isolated parkinsonism without dystonia or late-onset dystonia and a slower course.

Publication types

Case Reports

MeSH terms

Adult
Antiparkinson Agents / therapeutic use
Chromosome Aberrations
Dystonic Disorders / complications*
Dystonic Disorders / drug therapy
Dystonic Disorders / genetics*
Humans
Levodopa / therapeutic use
Male
Parkinsonian Disorders / complications*
Parkinsonian Disorders / drug therapy
Phenotype
X Chromosome / genetics*

Substances

Antiparkinson Agents
Levodopa