Maintaining low HIV type 1 env genetic diversity among injection drug users infected with a B/C recombinant and CRF01_AE HIV type 1 in southern China

AIDS Res Hum Retroviruses. 2002 Jan 20;18(2):167-70. doi: 10.1089/08892220252779719.

Abstract

HIV-1 outbreaks in Guangxi Province, southern China were initiated from two separate border cities in 1996 and 1997. Drug users in Pingxiang City, which borders Vietnam, were infected with CRF01_AE HIV-1, and drug users in Baise City, which borders Yunan Province, were infected with a novel B/C recombinant HIV-1. Since 1997, HIV-1 has been rapidly spreading in Guangxi, including its capital city Nanning. Survey data indicated that HIV-1 prevalence among IDUs in new outbreak regions increased 8 to 42% within 1 year. The B/C recombinants obtained from five separate regions in Guangxi, which span a 4-year time frame, were remarkable for their low intersubject env V3 diversity, less than 0.2%. Similarly, the CRF01_AE from IDUs over a 3-year time frame had low intersubject env V3 diversity of less than 1.6%. Different patterns of sequence variations in the V3 and V4 regions were observed for the B/C recombinant and the CRF01_AE HIV1. The rapid spreading of homogeneous HIV-1 strains in Guangxi may have important implications for HIV transmission as well as vaccine development and evaluation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • China / epidemiology
  • DNA, Viral
  • Disease Outbreaks*
  • Genetic Variation*
  • HIV Envelope Protein gp120 / genetics*
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Molecular Sequence Data
  • Peptide Fragments / genetics*
  • Population Surveillance
  • Recombination, Genetic
  • Sequence Homology, Amino Acid
  • Substance Abuse, Intravenous / complications
  • Substance Abuse, Intravenous / virology*

Substances

  • DNA, Viral
  • HIV Envelope Protein gp120
  • HIV envelope protein gp120 (305-321)
  • Peptide Fragments

Associated data

  • GENBANK/AF160737
  • GENBANK/AF160738
  • GENBANK/AF160739
  • GENBANK/AF160740
  • GENBANK/AF160746
  • GENBANK/AF160747
  • GENBANK/AF160748
  • GENBANK/AF160749
  • GENBANK/AF160750
  • GENBANK/AF160755
  • GENBANK/AY008715
  • GENBANK/AY008716
  • GENBANK/AY008717
  • GENBANK/AY008718
  • GENBANK/AY049921
  • GENBANK/AY049922
  • GENBANK/AY049923
  • GENBANK/AY049924
  • GENBANK/AY049925
  • GENBANK/AY049926
  • GENBANK/AY049927
  • GENBANK/AY049928
  • GENBANK/AY049929
  • GENBANK/AY049930
  • GENBANK/AY049931
  • GENBANK/AY049932
  • GENBANK/AY049933
  • GENBANK/AY049935
  • GENBANK/AY049936
  • GENBANK/AY049937
  • GENBANK/AY049938