Abstract
How checkpoint pathways recognise double-strand breaks has long been a mystery. Recent studies have found that two distinct checkpoint protein complexes associate independently with chromatin at the sites of DNA damage. Why do two distinct mechanisms recognise strand lesions, and what does this tell us about the checkpoint pathways?
MeSH terms
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Cell Cycle Proteins / metabolism
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Chromatin / metabolism
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DNA / genetics
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DNA / metabolism*
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DNA Damage*
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DNA Repair Enzymes
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DNA Repair*
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DNA-Binding Proteins*
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Endonucleases / metabolism
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Exodeoxyribonucleases*
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Macromolecular Substances
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Phosphoproteins / metabolism
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Saccharomyces cerevisiae Proteins / metabolism
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Saccharomyces cerevisiae* / genetics
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Saccharomyces cerevisiae* / metabolism
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Schizosaccharomyces pombe Proteins
Substances
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Cell Cycle Proteins
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Chromatin
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DNA-Binding Proteins
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Macromolecular Substances
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Phosphoproteins
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Saccharomyces cerevisiae Proteins
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Schizosaccharomyces pombe Proteins
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hus1 protein, S pombe
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rad9 protein
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DNA
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Endonucleases
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Exodeoxyribonucleases
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RAD1 protein, S cerevisiae
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three prime repair exonuclease 1
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DNA Repair Enzymes