DNA double-strand break repair from head to tail

Curr Opin Struct Biol. 2002 Feb;12(1):115-22. doi: 10.1016/s0959-440x(02)00297-x.

Abstract

DNA double-strand break repair is a complex process that requires multiple enzymatic and structural activities to rejoin or repair the broken DNA ends using one of several repair pathways. These enzymatic and structural activities include end detection, end processing and alignment of DNA ends. Recent structural and functional studies of the DNA double-strand break repair factors Mre11/Rad50, Ku70/80 and Xrcc4 show how these enzymes combine and assemble both enzymatic and structural activities in DNA double-strand break repair.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Antigens, Nuclear*
  • Archaeal Proteins / chemistry
  • Archaeal Proteins / physiology*
  • DNA / metabolism
  • DNA Helicases*
  • DNA Repair / physiology*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / physiology*
  • Endodeoxyribonucleases / chemistry
  • Endodeoxyribonucleases / physiology*
  • Exodeoxyribonucleases / chemistry
  • Exodeoxyribonucleases / physiology*
  • Ku Autoantigen
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / physiology*
  • Protein Conformation
  • Saccharomyces cerevisiae Proteins*

Substances

  • Antigens, Nuclear
  • Archaeal Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • XRCC4 protein, human
  • high affinity DNA-binding factor, S cerevisiae
  • Adenosine Triphosphate
  • DNA
  • Endodeoxyribonucleases
  • Exodeoxyribonucleases
  • Mre11 protein, archaeal
  • DNA Helicases
  • XRCC5 protein, human
  • Xrcc6 protein, human
  • Ku Autoantigen