Effect of ropinirole on sleep onset: a randomized, placebo-controlled study in healthy volunteers

J J Ferreira; M Galitzky; C Thalamas; M Tiberge; J L Montastruc; C Sampaio; O Rascol

doi:10.1212/wnl.58.3.460

Effect of ropinirole on sleep onset: a randomized, placebo-controlled study in healthy volunteers

Neurology. 2002 Feb 12;58(3):460-2. doi: 10.1212/wnl.58.3.460.

Authors

J J Ferreira¹, M Galitzky, C Thalamas, M Tiberge, J L Montastruc, C Sampaio, O Rascol

Affiliation

¹ Egas Moniz Research Center, Lisbon, Portugal.

PMID: 11839850
DOI: 10.1212/wnl.58.3.460

Abstract

Somnolence and "sleep attacks" have been reported as an adverse effect of several antiparkinsonian drugs. The authors document, in a placebo-controlled, randomized, double-blind, crossover study performed in 20 healthy volunteers, using the Multiple System Latency Test (MSLT) as primary outcome, that ropinirole reduces time to sleep onset in humans. Ropinirole therapy was not associated with daytime episodes of rapid eyes movement (REM) sleep.

Publication types

Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Cross-Over Studies
Disorders of Excessive Somnolence / chemically induced*
Dopamine Agonists / adverse effects*
Double-Blind Method
Humans
Indoles / adverse effects*
Receptors, Dopamine D2 / agonists
Receptors, Dopamine D3
Sleep / drug effects*
Sleep Stages / drug effects

Substances

DRD3 protein, human
Dopamine Agonists
Indoles
Receptors, Dopamine D2
Receptors, Dopamine D3
ropinirole