Abstract
Pentacyclic triterpenes (1) and (2) have been isolated from Mimusops elengi and assigned structures 3beta,6beta,19alpha,23-tetrahydroxy-urs-12-ene and 1beta-hydroxy-3beta-hexanoyllup-20 (29)-ene-23, 28-dioic acid, respectively, on the basis of spectroscopic studies including 2D-NMR. The compound 1 showed moderate inhibiting activity against beta-glucuronidase enzyme
MeSH terms
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Animals
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Cattle
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Chromatography, Thin Layer
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Glucuronidase / antagonists & inhibitors*
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Inhibitory Concentration 50
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Liver
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Mass Spectrometry
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Medicine, Traditional
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pakistan
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Plants, Medicinal / chemistry*
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Substrate Specificity
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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1beta-hydroxy-3beta-hexanoyllup-20 (29)-ene-23, 28-dioic acid
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3beta,6beta,19alpha,23-tetrahydroxy-urs-12-ene
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Enzyme Inhibitors
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Triterpenes
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Glucuronidase