Abstract
Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead, demonstrating that a peptide backbone is not essential for activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Biological Transport, Active / drug effects
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Drug Synergism
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Levofloxacin*
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Membrane Transport Modulators*
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Membrane Transport Proteins / antagonists & inhibitors*
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Microbial Sensitivity Tests
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Molecular Mimicry
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Molecular Structure
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Ofloxacin / pharmacology*
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Peptide Fragments / chemical synthesis*
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Peptide Fragments / chemistry
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Peptide Fragments / pharmacology*
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / physiology
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Structure-Activity Relationship
Substances
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Anti-Infective Agents
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Membrane Transport Modulators
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Membrane Transport Proteins
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Peptide Fragments
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Levofloxacin
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Ofloxacin