Abstract
Typical immune responses lead to prominent clonal expansion of antigen-specific T and B cells followed by differentiation into effector cells. Most effector cells die at the end of the immune response but some of these cells survive and form long-lived memory cells. The factors controlling the formation and survival of memory T cells are reviewed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adjuvants, Immunologic / metabolism
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Animals
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Antigen-Presenting Cells / immunology
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Antigens / metabolism
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Apoptosis
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Cell Differentiation
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Cell Division
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Cell Movement
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Cytokines / metabolism
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Homeostasis
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Humans
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Immunologic Memory*
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Lymphocyte Activation
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
Substances
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Adjuvants, Immunologic
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Antigens
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Cytokines