Objective: To observe the change of the macromolecular components of extracellular matrix of lamina cribrosa (LC) in experimental glaucoma.
Methods: Immunoperoxidase (ABC) staining method was used to investigate the changes of collagen type IV and laminin in the lamina cribrosa of 9 monkey eyes with experimental glaucoma.
Results: At the late stage of glaucoma, the labeling of collagen type IV and laminin were increased at pre-LC and LC area due to the accumulation of basement membrane-like materials.
Conclusion: The changes may be a selective response to elevated intraocular pressure. This response may alter the biochemical composition and the biomechanics of the lamina cribrosa.