Abstract
[reaction: see text] A novel, nonacetal (trifluoromethyl)deoxoartemisinin was prepared with good stereoselectivity. This compound was obtained by debromination of the 10 alpha-CF3-10-bromodeoxoartemisinin in the presence of tributyltin hydride at reflux in toluene without alteration of the endoperoxide bridge. It presented a reasonable antimalarial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / pharmacology
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Artemisia / chemistry
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Artemisinins / chemical synthesis*
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Artemisinins / pharmacology
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Drug Resistance
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Halogens / chemistry
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Inhibitory Concentration 50
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Plasmodium falciparum / drug effects
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology
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Stereoisomerism
Substances
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10-(trifluoromethyl)deoxoartemisinin
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Antimalarials
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Artemisinins
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Halogens
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Sesquiterpenes
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artemisinin