Objective: To report a case of invasive rhinocerebral aspergillosis (IRA) during myelosuppressive phase after chemotherapy and the treatment outcome.
Methods: A patient with acute non-lymphoblastic leukemia (M(2a)) occurred IRA during myelosuppressive phase after chemotherapy and was treated with amphotericin B (AmB, including AmB-L), garlicin, 5-flucytosine (5-FC), fluconazole, itraconazole, ketoconazole, econazole and griseofulvin with twice of cerebrotomy lesion resections and cerebral decompressions.
Results: Though the survival time of this patient is a little longer than the others, she finally died of uncontrolled infection.
Conclusion: For most of the IRA, there remains no effective treatment. The best treatment is AmB in combination with surgical excision.