Stereoselective construction of eight-membered carbocycles by brook rearrangement-mediated [3 + 4] annulation

Org Lett. 2002 Mar 21;4(6):1031-3. doi: 10.1021/ol0256318.

Abstract

[reaction: see text] A newly developed strategy for eight-membered carbocycles via [3 + 4] annulation that involves the combination of beta-substituted acryloylsilanes and enolates of cycloheptenone is described. A unique feature of this annulative approach is its capacity to generate, in two steps, eight-membered ring systems containing useful functionalities for further synthetic elaboration from readily available three- and four-carbon components.