Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

Genome Biol. 2002;3(3):REVIEWS1006. doi: 10.1186/gb-2002-3-3-reviews1006. Epub 2002 Feb 26.

Abstract

When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.

Publication types

  • Review

MeSH terms

  • Animals
  • Codon, Nonsense / genetics*
  • Exons / genetics
  • Humans
  • Models, Genetic
  • Protein Biosynthesis / genetics*
  • Quality Control
  • RNA Cap-Binding Proteins
  • RNA Splicing / genetics*
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / physiology

Substances

  • Codon, Nonsense
  • RNA Cap-Binding Proteins
  • RNA, Messenger
  • RNA-Binding Proteins