Abstract
We compared the efficacies of quinupristin-dalfopristin (Q-D; 30 mg/kg of body weight every 8 h) and vancomycin (60 mg/kg twice daily), alone or in combination with rifampin (10 mg/kg twice daily), in a rabbit model of methicillin-resistant Staphylococcus aureus knee prosthesis infection. In contrast to vancomycin, Q-D significantly reduced the mean log(10) CFU per gram of bone versus that for the controls. The combination of rifampin with either Q-D or vancomycin was significantly more effective than monotherapy.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / therapeutic use
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Antibiotics, Antitubercular / administration & dosage*
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Drug Synergism
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Drug Therapy, Combination / pharmacokinetics
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Drug Therapy, Combination / therapeutic use*
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Joint Prosthesis*
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Methicillin Resistance
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / microbiology
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Rabbits
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Rifampin / administration & dosage*
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Tissue Distribution
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Vancomycin / pharmacokinetics
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Vancomycin / therapeutic use
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Virginiamycin / administration & dosage*
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Virginiamycin / analogs & derivatives
Substances
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Anti-Bacterial Agents
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Antibiotics, Antitubercular
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Virginiamycin
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quinupristin
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Vancomycin
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Rifampin