Abstract
To synthesize new highly active taxoids, we designed and synthesized 9 beta-dihydro-9,10-acetal taxoids. In vitro study of these analogues clearly showed them to be more potent than docetaxel.
MeSH terms
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Acetals / chemical synthesis*
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Acetals / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Docetaxel
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Drug Screening Assays, Antitumor
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Humans
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Neoplasms / drug therapy
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Paclitaxel / analogs & derivatives*
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Paclitaxel / chemical synthesis*
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Paclitaxel / pharmacology
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Structure-Activity Relationship
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Taxoids*
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Tumor Cells, Cultured / drug effects*
Substances
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Acetals
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Antineoplastic Agents
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Taxoids
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Docetaxel
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Paclitaxel