Abstract
The purpose of this study was to investigate the effects of [Nphe1]nociceptin(1-13)-NH2 on nociceptin-induced decreases in mean arterial pressure (MAP), heart rate (HR), and hindquarters vascular bed resistance (HVBR) of the anesthetized rat. The results showed that i.c.v. or i.v. [Nphe1]nociceptin(1-13)-NH2 (1.5-12 nmol/kg and 5-120 nmol/kg, respectively) could antagonize the depressor effects of i.c.v. or i.v. nociceptin (3 and 30 nmol/kg, respectively) on MAP and HR. Furthermore, [Nphe1]nociceptin(1-13)-NH2 (5-120 nmol/kg) could reverse nociceptin (30 nmol/kg)-induced decrease of HVBR. However, [Nphe1]nociceptin(1-13)-NH2 had no significant effects on similar effects induced by morphine. Our results suggest that [Nphe1]nociceptin(1-13)-NH2 acts as a selective antagonist of the nociceptin receptor in the cardiovascular system of the rat.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anesthesia*
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Animals
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Blood Pressure / drug effects*
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Dose-Response Relationship, Drug
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Female
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Heart Rate / drug effects*
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Hindlimb / blood supply
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Injections, Intravenous
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Injections, Intraventricular
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Male
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Morphine / antagonists & inhibitors
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Morphine / pharmacology
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Naloxone / pharmacology
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Narcotic Antagonists / pharmacology
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Narcotics / pharmacology
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Nociceptin
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Opioid Peptides / antagonists & inhibitors*
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Opioid Peptides / therapeutic use*
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Peptide Fragments / therapeutic use*
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Rats
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Rats, Wistar
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Regional Blood Flow / drug effects
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Vascular Resistance / drug effects
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Vasodilation / drug effects*
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Vasodilator Agents / antagonists & inhibitors*
Substances
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Narcotic Antagonists
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Narcotics
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Opioid Peptides
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Peptide Fragments
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Vasodilator Agents
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nociceptin-(1-13)-NH2, NPhe(1)-
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Naloxone
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Morphine