pH-dependent binding modes observed in trypsin crystals: lessons for structure-based drug design

Chembiochem. 2002 Mar 1;3(2-3):246-9. doi: 10.1002/1439-7633(20020301)3:2/3<246::aid-cbic246>3.0.co;2-#.
No abstract available

MeSH terms

  • Animals
  • Binding Sites
  • Cattle
  • Crystallization
  • Crystallography, X-Ray
  • Drug Design
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Factor Xa / chemistry
  • Factor Xa Inhibitors*
  • Hydrogen-Ion Concentration
  • Models, Molecular
  • Structure-Activity Relationship
  • Trypsin / chemistry
  • Trypsin / metabolism*

Substances

  • Enzyme Inhibitors
  • Factor Xa Inhibitors
  • Trypsin
  • Factor Xa