Myocardial contrast echocardiography (MCE) has seen a significant evolution of its clinical application with the advent of newer microbubbles suitable for intravenous administration and development of ultrasound imaging technologies. These new technologies, which are specifically aimed to improve our ability to visualize these microbubbles in the myocardial circulation, require the user to have an understanding of the basis for optimal use in the clinical setting. The discussion below aims to provide a summary of these new microbubble technologies.