Abstract
The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum samples from 5 patients with probable cerebral aspergillosis and from 16 control patients. Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally. Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Fungal / analysis*
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Antigens, Fungal / blood
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Aspergillus / isolation & purification*
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Bone Marrow Transplantation / adverse effects*
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Cerebral Cortex / microbiology
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Cerebral Cortex / pathology
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Cerebrospinal Fluid / microbiology*
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Enzyme-Linked Immunosorbent Assay / methods
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Galactose / analogs & derivatives
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Humans
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Mannans / analysis*
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Mannans / blood
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Neuroaspergillosis / diagnosis*
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Neuroaspergillosis / microbiology
Substances
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Antigens, Fungal
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Mannans
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galactomannan
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Galactose