Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort

Transplantation. 2002 Mar 27;73(6):1009. doi: 10.1097/00007890-200203270-00035.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Antidepressive Agents / therapeutic use*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / biosynthesis*
  • Drug Interactions
  • Drug Monitoring
  • Enzyme Induction / drug effects
  • Germany
  • Humans
  • Hypericum*
  • Immunosuppressive Agents / adverse effects*
  • Kidney / drug effects
  • Kidney / pathology*
  • Kidney Transplantation / immunology*
  • Male
  • Mixed Function Oxygenases / biosynthesis*
  • Phytotherapy*
  • Plant Preparations / therapeutic use*
  • Tacrolimus / adverse effects*
  • Tacrolimus / blood
  • Tacrolimus / pharmacokinetics

Substances

  • Antidepressive Agents
  • Immunosuppressive Agents
  • Plant Preparations
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Tacrolimus