Randomized clinical trials in advanced and metastatic colorectal carcinoma

Surg Oncol Clin N Am. 2002 Jan;11(1):173-91, ix. doi: 10.1016/s1055-3207(03)00080-2.

Abstract

The treatment of advanced colorectal cancer has long been a dilemma for clinicians. After many years of therapy limited to 5-fluorouracil (5-FU)-based chemotherapy, a number of new discoveries have significantly advanced this field in the last decade. The advent of irinotecan has given us hope for a second line chemotherapeutic agent and a possible new combination for first line chemotherapy.

Publication types

  • Review

MeSH terms

  • Antimetabolites, Antineoplastic / therapeutic use*
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / pathology
  • Evidence-Based Medicine
  • Fluorouracil / therapeutic use*
  • Humans
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / secondary
  • Medical Oncology
  • Prospective Studies
  • Randomized Controlled Trials as Topic*

Substances

  • Antimetabolites, Antineoplastic
  • Fluorouracil