Abstract
A young Down's syndrome patient developed tricuspid valve endocarditis several years after undergoing surgical closure of a congenital ventricular septal defect. Fungal etiology was established by PCR amplification of the Candida albicans ERG11 gene. Although antifungal therapy was administered, surgical replacement of the infected valve was required to eliminate the infection.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antifungal Agents / therapeutic use
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Candida albicans / genetics*
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Candida albicans / isolation & purification*
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Candidiasis / complications
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Candidiasis / diagnosis*
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Candidiasis / microbiology*
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Candidiasis / therapy
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Child, Preschool
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Critical Illness
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Down Syndrome / complications
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Endocarditis / complications
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Endocarditis / diagnosis*
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Endocarditis / microbiology*
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Endocarditis / therapy
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Female
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Fluconazole / therapeutic use
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Genes, Fungal / genetics
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Heart Valve Prosthesis / microbiology
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Humans
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Polymerase Chain Reaction
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Prosthesis-Related Infections / complications
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Prosthesis-Related Infections / diagnosis*
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Prosthesis-Related Infections / microbiology*
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Prosthesis-Related Infections / therapy
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Tricuspid Valve / microbiology
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Tricuspid Valve / surgery
Substances
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Antifungal Agents
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Fluconazole