[Tissue microarrays, or the advent of chips in pathology]

Ann Pathol. 2002 Feb;22(1):69-72.
[Article in French]

Abstract

Tissue microarray technology is a new method used to analyze several hundred tumor samples on a single slide allowing high throughput analysis of genes and proteins on a large cohort. The method consists to core tissues from paraffin-embedded tissue donor blocks and placing them into a single paraffin block. Despite the low amount of tissue analyzed by tissue microarray, different studies have demonstrated a high concordance of protein expression between this technique and the conventional tissue sections.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Humans
  • Immunohistochemistry*
  • Neoplasm Proteins / analysis
  • Neoplasms / chemistry*
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Paraffin
  • Pathology / methods*
  • Tissue Embedding

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Paraffin