Abstract
We have previously shown that Vpu is rarely targeted by HIV-1-specific cytotoxic T lymphocytes (CTL). The present report extends these findings and describes the characterization of the first CTL epitope within HIV-1 Vpu, identified in an individual with long-term non-progressive HIV-1 infection. The epitope was shown to be highly conserved among HIV clade B sequences and is restricted by HLA-A*3303, an HLA allele commonly seen in Asian and west-African populations.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Consensus Sequence
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Cytotoxicity, Immunologic
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Disease Progression
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HIV Infections / immunology*
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HIV Infections / virology
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HIV Long-Term Survivors
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HIV-1 / immunology*
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HLA-A Antigens / immunology*
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Human Immunodeficiency Virus Proteins
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Humans
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Molecular Sequence Data
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Peptide Fragments / chemistry
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Peptide Fragments / immunology*
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T-Lymphocytes, Cytotoxic / immunology*
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Viral Regulatory and Accessory Proteins / immunology*
Substances
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HLA-A Antigens
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HLA-A*33 antigen
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Human Immunodeficiency Virus Proteins
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Peptide Fragments
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Viral Regulatory and Accessory Proteins
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vpu protein, Human immunodeficiency virus 1