[Telomerase activity and regulation in human neuroepithelial tumors]

Zhonghua Wai Ke Za Zhi. 2002 Feb;40(2):90-3.
[Article in Chinese]

Abstract

Objective: To investigate telomerase activity and expression of hTR and hTERT in human neuroepithelial tumors for exploring new strategy for clinical diagnosis and treatment.

Methods: Telomerase activity was detected by modified TRAP method and the expression of hTR and hTERT was measured by RT-PCR method in 65 human neuroepithelial tumors, respectively.

Results: The positive rates of telomerase and hTERT were 61.54% and 70.77% respectively in human neuroepithelial tumors, and the positive rate and their level of expression were correlated with the degree of malignancy of tumors positively.

Conclusions: Telomerase activity and hTERT are significantly correlated with the degree of malignancyin human neuroepithelial tumors. hTERT may play a key role in the regulation of telomerase activity.

Publication types

  • English Abstract

MeSH terms

  • DNA-Binding Proteins
  • Gene Expression Regulation, Enzymologic*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neoplasms, Neuroepithelial / enzymology*
  • Neoplasms, Neuroepithelial / genetics
  • Telomerase / biosynthesis
  • Telomerase / genetics
  • Telomerase / metabolism*

Substances

  • DNA-Binding Proteins
  • Telomerase