Abstract
The discovery of 2-acylamino-2-phenylethyl disodium phosphates and as structurally novel inhibitors of TNF-alpha production is reported. Structure-activity relationships (SARs) are also discussed.
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / chemical synthesis*
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Adjuvants, Immunologic / pharmacology
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Animals
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Benzylamines / administration & dosage
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Benzylamines / chemical synthesis*
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Benzylamines / pharmacology
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Lipopolysaccharides / administration & dosage
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Male
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Mice
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Mice, Inbred BALB C
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Phosphates / chemistry
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Rats
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Rats, Sprague-Dawley
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Stereoisomerism
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Structure-Activity Relationship
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Adjuvants, Immunologic
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Benzylamines
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Lipopolysaccharides
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Phosphates
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Tumor Necrosis Factor-alpha