Abstract
Mechanisms for tetracycline and macrolide resistance in 54 isolates of erythromycin-resistant Streptococcus agalactiae were analyzed by PCR. The erm(B), erm(A), and mef(A) genes, either alone or in combination, were detected in all the erythromycin-resistant isolates. The tet(M) and tet(O) genes were responsible for tetracycline resistance. Random amplification of polymorphic DNA indicated different clonal origins of the isolates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Drug Resistance, Bacterial / genetics*
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Erythromycin / pharmacology*
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Humans
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Microbial Sensitivity Tests
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Polymerase Chain Reaction
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Random Amplified Polymorphic DNA Technique
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Streptococcal Infections / microbiology
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Streptococcus agalactiae / drug effects*
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Streptococcus agalactiae / genetics
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Tetracycline / pharmacology*
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Tetracycline Resistance / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Erythromycin
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Tetracycline