Automated parallel solid-phase synthesis of non-peptide CCR1 receptor antagonists

Comb Chem High Throughput Screen. 2002 May;5(3):249-51. doi: 10.2174/1386207024607284.

Abstract

An automated, parallel, solid-phase synthesis and screening strategy using commercially available aryl acetic acids as starting materials has discovered novel, non-peptide CCR1 antagonists (K(i) < 100 nM).

MeSH terms

  • Acetates / chemical synthesis
  • Acetates / chemistry
  • Anti-Inflammatory Agents / chemical synthesis*
  • Chromatography, High Pressure Liquid
  • Combinatorial Chemistry Techniques
  • Magnetic Resonance Spectroscopy
  • Receptors, CCR1
  • Receptors, Chemokine / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Acetates
  • Anti-Inflammatory Agents
  • Receptors, CCR1
  • Receptors, Chemokine