Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis

Semin Cell Dev Biol. 2002 Feb;13(1):9-18. doi: 10.1006/scdb.2001.0286.

Abstract

Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic vasculature. These studies are aimed at targeting the lymphatic vasculature in the treatment of various diseases, such as tumour metastasis and lymphoedema.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Angiogenesis Inducing Agents / metabolism
  • Angiopoietin-2
  • Animals
  • Chylothorax / genetics
  • DNA-Binding Proteins / genetics
  • Endothelium, Vascular / physiology*
  • Forkhead Transcription Factors
  • Glycoproteins / metabolism
  • Homeodomain Proteins / metabolism
  • Humans
  • Integrins / metabolism
  • Ligands
  • Lymphatic Metastasis / physiopathology*
  • Lymphatic System / embryology
  • Lymphatic System / physiology*
  • Lymphedema / genetics
  • Lymphedema / physiopathology*
  • Membrane Glycoproteins / metabolism
  • Membrane Transport Proteins
  • Mice
  • Mice, Transgenic
  • Neovascularization, Physiologic
  • Neuropilin-2 / metabolism
  • Oncogene Proteins / genetics
  • Prospero-Related Homeobox 1 Protein
  • Proto-Oncogene Proteins c-ets
  • Receptors, Chemokine / metabolism
  • Transcription Factors / genetics
  • Tumor Suppressor Proteins
  • Vascular Endothelial Growth Factor Receptor-3 / metabolism
  • Vesicular Transport Proteins

Substances

  • Angiogenesis Inducing Agents
  • Angiopoietin-2
  • DNA-Binding Proteins
  • Elk3 protein, mouse
  • Forkhead Transcription Factors
  • Glycoproteins
  • Gp38 protein, mouse
  • Homeodomain Proteins
  • Integrins
  • LYVE1 protein, human
  • Ligands
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Neuropilin-2
  • Oncogene Proteins
  • PDPN protein, human
  • Proto-Oncogene Proteins c-ets
  • Receptors, Chemokine
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Vesicular Transport Proteins
  • Xlkd1 protein, mouse
  • integrin alpha 9 beta 1
  • mesenchyme fork head 1 protein
  • Prospero-Related Homeobox 1 Protein
  • Vascular Endothelial Growth Factor Receptor-3