A 48-year-old female with bronchiectasis after pulmonary tuberculosis was admitted to our hospital because of bloody sputum and multiple cavity formation in the right lung. Chest X-ray & CT films revealed diffuse nodular shadows and cavity formation with a thick wall. Nocardia asteroides was isolated from the stum but no other pathogenic bacteria was isolated. Administration of sulfame-thoxazole-trimethoprim is not effective. The results of an MIC test for antimicrobial agents led to treatment with sparfloxacin and the clinical symptoms and cavity formations in the right lung improved. Nocardia asteroides may cause exacerbation of bronchiectasis.