Abstract
The role of maternal humoral immune response and viral load was analyzed in relation to the incidence of mother-to-child transmission (MTCT) of infants born to HIV-1 subtype C infected mothers. High levels of viral RNA in the serum correlated with MTCT as did high titers of subtype C consensus V3 peptide binding antibodies (BA) and neutralizing antibody (NA) to subtype B HIV-1MN. Logistic regression analysis showed that maternal viral load and V3 peptide subtype C BA were independent predictors for MTCT, odds ratio (OR) = 2.22 and OR = 2.52, respectively. No correlation between NA to homologous HIV-1 subtype C virus and MTCT was found. BA to V3 peptides may provide a rapid inexpensive method that can be used to determine the risk of HIV-1 MTCT.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Female
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HIV Antibodies / blood*
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HIV Envelope Protein gp120 / genetics
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HIV Envelope Protein gp120 / immunology*
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HIV Infections / transmission*
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HIV Infections / virology
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HIV-1 / classification
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HIV-1 / immunology*
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Humans
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Infant, Newborn
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Infectious Disease Transmission, Vertical*
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Logistic Models
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Molecular Sequence Data
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Neutralization Tests
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Peptide Fragments / chemical synthesis
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Peptide Fragments / genetics
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Peptide Fragments / immunology*
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Pregnancy
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Pregnancy Complications, Infectious / virology
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RNA, Viral / blood
Substances
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HIV Antibodies
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HIV Envelope Protein gp120
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HIV envelope protein gp120 (305-321)
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Peptide Fragments
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RNA, Viral